In Press

Holsen LM, Hoge WS, Lennerz BS, Cerit H, Hye T, Moondra P, Goldstein JM, Ebbeling CB, Ludwig DS. Diets varying in carbohydrate content differentially alter brain activity in homeostatic and reward regions in adults. J Nutr, in press.

Kerem L*, Holsen LM*, Fazeli P, Bredella MA, Mancuso C, Resulaj M, Holmes TM, Klibanski A, Lawson EA. Modulation of neural fMRI responses ot visual food cues to overeating and fasting interventions: A preliminary study. Physiol Rep, in press.

Holsen LM*, Huang G*, Cherkerzian S, Aroner S, Loucks EB, Buka S, Handa RJ, Goldstein JM. Sex differences in hemoglobin A1c levels related to comorbidity of obesity and depression. J Women’s Health, in press.

Kerem L, Van De Water AL, Kuhnle MC, Harshman S, Hauser K, Eddy KT, Becker KR, Misra M, Micali N, Thomas JT, Holsen LM*, Lawson EA*., Neurobiology of avoidant/restrictive food intake disorder in youth with overweight/obesity versus healthy weight. J Clin Child Adolesc Psychol, in press.

Duda JM, Moser AD, Zuo CS, Du F, Chen X, Perlo S, Richards CE, Nascimento N, Ironside M, Crowley DJ, Holsen LM, Misra M, Hudson JI, Goldstein JM, Pizzagalli DA. Repeatability and reliability of GABA measurements with magnetic resonance spectroscopy in healthy young adults. Magn Reson Med, in press.

Goldstein JM, Cohen JE, Mareckova KM, Holsen LM, Whitfield-Gabrieli S, Gilman SE, Buka SL, Hornig M. Impact of prenatal maternal cytokine exposure on sex differences in brain circuitry regulating stress in offspring 45 years later. PNAS, in press.


Kerem L, Hadjikhani N, Holsen LM, Lawson EA, Plessow F. Oxytocin reduces functional connectivity between brain regions involved in eating behavior in men with overweight and obesity. Int J Obesity, 2020; 44:980-989. doi: 10.1038/s41366-019-0489-7

Garcia RG, Mareckova K, Holsen LM, Cohen JE, Whitfield-Gabrieli S, Napadow V, Barbieri R, Goldstein JM. Impact of sex and depressed mood on the central regulation of cardiac autonomic function. Neuropsychopharmacology 2020; 45:1280-1288.

Breithaupt L, Chunga-Iturry N, Lyall AE, Cetin-Karayumak S, Becker KR, Thomas JJ, Slattery M, Makris N, Plessow F, Pasternak O, Holsen LM, Kubicki M, Misra M, Lawson EA, Eddy KT. Developmental stage-dependent relationships between ghrelin levels and hippocampal white matter connections in low-weight anorexia nervosa and atypical anorexia nervosa. Psychoneuroendocrinology 2020; 119:104772.



Cerit H, Davidson P, Hye T, Moondra P, Haimovici F, Sogg S, Shikora S, Goldstein JM, Evins AE, Whitfield-Gabrieli S, Stoeckel LE, Holsen LM. Resting state brain connectivity as a predictor of long-term weight loss and changes related to cognitive control of eating behavior following bariatric surgery. Obesity 2019; 27:1846-1855. doi: 10.1002/oby.22607

Cerit H, Christensen KA, Moondra P, Klibanski A, Goldstein JM, Holsen LM. Divergent associations between ghrelin and neural responsivity to palatable food in hyperphagic and hypophagic recurrent depression. J Affect Disord. 2019; 242:29-38. doi: 10.1016/j.jad.2018.07.088




Plessow F, Marengi DA, Perri SK, Felicione JM, Franklin R, Hollmes TM, Holsen LM, Makris N, Deckersbach T, Lawson EA. Effects of intranasal oxytocin on the blood oxygen level-dependent signal in food motivation and cognitive control pathways in overweight and obese men. Neuropsychopharmacology 2018; 43:638-45. doi: 10.1038/npp.2017.226




Mareckova K, Holsen L, Admon R, Whitfield-Gabrieli S, Seidman LJ, Buka SL, Klibanski A, Goldstein JM. Neural – hormonal responses to negative affective stimuli: Impact of dysphoric mood and sex. J Affect Disord. 2017; 222:88-97. doi: 10.1016/j.jad.2017.06.050


Holsen LM*, Jackson B*. Reward capacity predicts leptin dynamics during laboratory-controlled eating in women as a function of body mass index. Obesity 2017; 25:1564-1568. doi: 10.1002/oby.21930


Holsen LM, Davidson P, Cerit H, Hye T, Moondra P, Haimovici F, Sogg S, Shikora S, Goldstein JM, Evins AE, Stoeckel LE. Neural predictors of 12-month weight loss outcomes following bariatric surgery. Int J Obesity 2017; Aug 14 [Epub ahead of print] doi: 10.1038/ijo.2017.190 




Mareckova K, Holsen LM, Admon R, Makris N, Seidman L, Buka S, Whitfield-Gabrieli S, Goldstein JM. Brain activity and connectivity in response to negative affective stimuli: Impact of dysphoric mood and sex across diagnoses. Hum Brain Mapp. 2016; 27:3733-44. doi: 10.1002/hbm.23271


Goldstein JM, Holsen L, Huang G, Hammond BD, James-Todd T, Cherkerzian S, Hale TM, Handa RJ. Prenatal stress-immune programming of sex differences in comorbidity of depression and obesity/metabolic syndrome. Dialogues in Clinical Neurosci. 2016; 18:425-436. PMID: 28179814




Jacobs EG, Holsen LM, Lancaster K, Makris N, Whitfield-Gabrieli S, Remington A, Weiss B, Buka S, Klibanski A, Goldstein JM. 17β-Estradiol differentially regulates stress circuitry activity in healthy and depressed women. Neuropsychopharmacology. 2015; 40:566-76. doi: 10.1038/npp.2014.203


Admon R, Holsen LM, Aizley H, Remington A, Whitfield-Gabrieli S, Goldstein JM, Pizzagalli DA. Striatal hyper-sensitivity during stress in remitted individuals with recurrent depression. Biol Psychiatry. 2015; 78:67-76. doi: 10.1016/j.biopsych.2014.09.019


Müller TD, Kojima M, Nogueiras R, Andermann ML, Andrews ZB, Anker SD, Argente J, Batterham R, Benoit SC, Bowers CY, Broglio F, Brown MS, Casanueva F, D’Alessio D, Depoortere I, Geliebter A, Ghigo E, Cole PA, Cowley M, Cummings DE, Dagher A, Diano S, Dickson SL, Diéguez C, Goldstein JL, Granata R, Grill HJ, Grove K, Habegger KM, Heppner K, Heiman ML, Holsen L, Holst B, Inui A, Jansson JO, Kirchner H, Korbonits M, Laferrère B, LeRoux CW, Lopez M, Morin S, Nakazato M, Nass R, Perez-Tilve D, Pfluger PT, Schwartz TW, Seeley RJ, Sleeman M, Sun Y, Sussel L, Tong J, Thorner MO, van der Lely AJ, van der Ploeg LHT, Zigman JM, Kangawa K, Smith RG, Horvath T, Tschöp MH. Ghrelin. Mol Metab. 2015; 4:437-60. doi: 10.1016/j.molmet.2015.03.005


Goldstein JM, Abbs B, Lancaster K, Longenecker JM, Holsen LM, Cherkerzian S, Whitfield-Gabrieli S, Makris N, Tsuang MT, Buka SL, Seidman LJ, Klibanski A. Sex differences, hormones, and fMRI stress response circuitry deficits in psychosis. Psychiatry Res. 2015; 232:226-36. doi: 10.1016/j.pscychresns.2015.03.006




Holsen LM*, Lawson EA*, Christensen K, Klibanski A, Goldstein JM. Abnormal relationships between the neural response to high- and low-calorie foods and endogenous acylated ghrelin in women with active and weight-recovered anorexia nervosa. Psychiatric Res: Neuroimaging 2014; 223:94-103. doi: 10.1016/j.pscychresns.2014.04.015


Goldstein JM, Holsen LM, Handa R, Tobet S. Fetal hormonal programming of sex differences in depression: Linking women’s mental health with sex differences in the brain across the lifespan. Front Neurosci. 2014; 8:247. doi: 10.3389/fnins.2014.00247




Lawson EA, Holsen LM, Santin M, DeSanti R, Meenaghan E, Eddy KT, Herzog DB, Goldstein JM, Klibanski A. Postprandial oxytocin secretion is associated with severity of anxiety and depressive symptoms in anorexia nervosa. J Clin Psych. 2013;74:E451-7. doi: 10.4088/JCP.12m08154


Lennerz BS, Alsop DC, Holsen LM, Stern E, Rojas R, Ebbeling CB, Goldstein JM, Ludwig DS. Effects of dietary glycemic index on brain regions related to reward and craving in men. Am J Clin Nutr. 2013; 98:641-7. doi: 10.3945/ajcn.113.064113


Holsen LM, Lancaster K, Klibanski A, Whitfield-Gabrieli S, Cherkerzian S, Buka S, Goldstein JM. HPA-axis hormone modulation of stress response circuitry activity in women with remitted major depression. Neurosci. 2013; 250:733-42. doi: 10.1016/j.neuroscience.2013.07.042


Lawson EA*, Holsen LM*, Desanti R, Santin M, Meenaghan E, Herzog DB, Goldstein JM, Klibanski A. Increased hypothalamic-pituitary-adrenal drive is associated with decreased appetite and hypoactivation of food motivatino neurocircuitry in anorexia nervosa. Eur J Endocrinol. 2013; 169:639-47. doi: 10.1530/EJE-13-0433




Holsen LM, Savage CR, Martin LE, Bruce AS, Lepping RJ, Ko E, Brooks WM, Butler MG, Zarcone JR, Goldstein JM. Importance of reward and prefrontal circuitry in hunger and satiety: Prader-Willi syndrome vs. simple obesity. Int J Obesity. 2012;36:638-47. doi: 10.1038/ijo.2011.204


 Honea RA, Holsen LM, Lepping RJ, Perea R, Butler MG, Brooks WM, Savage CR. The neuroanatomy of genetic subtype differences in Prader-Willi syndrome. Am J Med Genet B Neuropsychiatr Genet. 2012;159B:243-53. doi: 10.1002/ajmg.b.32022


Holsen LM, Lee J-H, Spaeth SB, Ogden LA, Klibanski A, Whitfield-Gabrieli S, Sloan RP, Goldstein JM. Brain hypoactivation, autonomic nervous system dysregulation, and gonadal hormones in depression: A preliminary study. Neurosci Lett. 2012;524:57-61. doi: 10.1016/j.neulet.2012.02.056


Holsen LM, Lawson EA, Ko E, Blum J, Makris N, Fazeli, PK, Klibanksi A, Goldstein JM. Food motivation circuitry hypoactivation related to hedonic and non-hedonic aspects of hunger and satiety in women with active and weight-restored anorexia nervosa. J Psychiatry Neurosci. 2012;37:322-32. doi: 10.1503/jpn.110156


Bruce J, Hancock L, Bruce A, Lepping R, Martin L, Lundgren J, Malley S, Holsen L, Savage C. Changes in brain activation to food pictures following adjustable gastric banding. Surg Obes Relat Dis. 2012;8:602-8. doi: 10.1016/j.soard.2011.07.006


Lawson EA, Holsen LM, Santin M, Meenaghan E, Eddy KT, Becker AE, Herzog DB, Goldstein JM, Klibanski A. Oxytocin secretion is associated with severity of disordered eating psychopathology and insular cortex hypoactivation in anorexia nervosa. J Clin Endocrinol Metab. 2012;97:E1898-908. doi: 10.1210/jc.2012-1702




Holsen LM, Spaeth SB, Lee J-H, Ogden LA, Klibanski A, Whitfield-Gabrieli S, Goldstein JM. Stress response circuitry hypoactivation related to hormonal dysfunction in women with major depression. J Affect Disord. 2011;131:279-87. doi: 10.1016/j.jad.2010.11.024


2010 and earlier


Bruce AS, Holsen LM, Chambers RJ, Martin LE, Brooks WM, Zarcone JR, Butler MG, Savage CR. Obese children show hyperactivation to food pictures in brain networks linked to motivation, reward, and cognitive control. Int J Obesity. 2010;10:1494-1500. doi: 10.1038/ijo.2010.84


Martin LE, Holsen LM, Chambers RJ, Bruce AS, Brooks WM, Zarcone JR, Butler MG, Savage CR. Neural mechanisms associated with food motivation in obese and healthy weight adults. Obesity. 2010;18:254-60. doi: 10.1038/oby.2009.220

Holsen LM, Zarcone JR, Chambers RJ, Butler MG, Bittel D, Brooks WM, Thompson TI, Savage CR. Genetic subtype differences in neural circuitry of food motivation in Prader-Willi syndrome. Int J Obesity. 2009;33:273-83. doi: 10.1038/ijo.2008.255

Dalton KM, Holsen LM, Abbeduto LJ, McDuffie A, Davidson RJ. Brain function and gaze-fixation during facial emotion processing in fragile X and autism. Autism Res. 2008;1:231-9. doi: 10.1002/aur.32

Holsen LM, Dalton KM, Johnstone T, Davidson RJ. Prefrontal social cognition network dysfunction underlying face encoding and social anxiety in fragile X syndrome. Neuroimage. 2008;43:592-604. doi: 10.1016/j.neuroimage.2008.08.009

Zarcone J, Napolitano D, Peterson C, Breidbord J, Ferraioli S, Caruso-Anderson M, Holsen L, Butler MG, Thompson T. The relationship between compulsive behaviour and academic achievement across the three genetic subtypes of Prader-Willi syndrome. J Intellect Disabil Res. 2007;51:478-87. doi: 10.1111/j.1365-2788.2006.00916.x

Holsen LM, Zarcone JR, Brooks WM, Butler MG, Thompson TI, Ahluwalia JS, Nollen NL, Savage CR. Neural mechanisms underlying hyperphagia in Prader-Willi syndrome. Obesity. 2006;14:1028-37. doi: 10.1038/oby.2006.118

Okuyemi KS, Powell JN, Savage CR, Hall SB, Nollen NL, Holsen LM, McClernon FJ, Ahluwalia JS. Cue-elicited brain activation in African American and Caucasian smokers. Addict Biol. 2006;11:97-106. doi: 10.1111/j.1369-1600.2006.00007.x

Young J, Zarcone J, Holsen LM, Anderson MC, Hall S, Richman D, Butler MG, Thompson TI. A measure of food seeking in Prader-Willi syndrome. J Intellect Disabil Res. 2006;50:18-24. doi: 10.1111/j.1365-2788.2005.00724.x

Holsen LM, Zarcone JR, Thompson TI, Brooks WM, Anderson M, Ahluwalia J, Nollen NL, Savage CR. Neural mechanisms underlying hunger in children and adolescents: An fMRI study.  Neuroimage. 2005;27:669-76. doi: 10.1016/j.neuroimage.2005.04.043


Holsen LM, Thompson TI. Compulsive behavior and eye blink in Prader-Willi syndrome: Neurochemical implications. Am J Ment Retard. 2004;109:197-207. PMID: 15072522